Creatinine Clearance Using 24-Hour Urine
Ccr (mL/min) = (Urine Cr × (Urine Volume [24hr urine] / 1440)) / Serum Cr
(BSA correction(1.73/BSA) is recommended for accurate GFR assessment)
Ccr (mL/min/1.73㎡) = {(Urine Cr × (Urine Volume / 1440)) / Serum Cr} × (1.73[㎡] / BSA[㎡])
BSA (Mosteller) : √[(Height(cm) × Weight(kg)) / 3600]
※ Without height and weight, BSA-adjusted value will not be shown.
※ In advanced CKD, tubular secretion of creatinine increases, potentially overestimating GFR.
※ Always verify adequacy of urine collection (see tool below).
Urine Collection Adequacy Evaluation
Normal 24hr Creatinine Excretion:
[Age 20–50] Male: 18.5–25.0 | Female: 16.5–20.2 mg/kg/day
[Age 50–70] Male: 15.7–20.2 | Female: 11.8–16.1 mg/kg/day
(Ref.: Comprehensive Clinical Nephrology 3rd ed.)