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Integrated LDL-Cholesterol Calculator (Friedewald / Martin-Hopkins / Sampson)

Friedewald: LDL = TC – HDL – (TG/5)
Martin-Hopkins: LDL = TC – HDL – (TG / adjustable factor)
Sampson: LDL = (TC / 0.948) – (HDL / 0.971) – ((TG / 8.56) + (TG × non-HDL / 2140) – (TG² / 16100) – 9.44
Non-HDL = TC – HDL







* If TG ≥ 400 mg/dL, LDL-C values using Friedewald and Martin-Hopkins formulas may be inaccurate. Use with caution!

Reference :
Martin SS, Blaha MJ, Elshazly MB, et al. Comparison of a Novel Method vs the Friedewald Equation for Estimating Low-Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile. JAMA. 2013;310(19):2061–2068. doi:10.1001/jama.2013.280532
Sampson M, Ling C, Sun Q, et al. A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia. JAMA Cardiol. 2020;5(5):540–548. doi:10.1001/jamacardio.2020.0013

Non-HDL-C (mg/dL)
TG (mg/dL)<100100–129130–159160–189190–219≥220
7-493.53.43.33.33.23.1
50-5643.93.73.63.63.4
57-614.34.143.93.83.6
62-664.54.34.143.93.9
67-714.74.44.34.24.13.9
72-754.84.64.44.24.24.1
76-794.94.64.54.34.34.2
80-8354.84.64.44.34.2
84-875.14.84.64.54.44.3
88-925.24.94.74.64.44.3
93-965.354.84.74.54.4
97-1005.45.14.84.74.54.3
101-1055.55.254.74.64.5
106-1105.65.354.84.64.5
111-1155.75.45.14.94.74.5
116-1205.85.55.254.84.6
121-12665.55.354.84.6
127-1326.15.75.35.14.94.7
133-1386.25.85.45.254.7
139-1466.35.95.65.354.8
147-1546.565.75.45.14.8
155-1636.76.25.85.45.24.9
164-1736.86.35.95.55.35
174-18576.565.75.45.1
186-2017.36.76.25.85.55.2
202-2207.66.96.465.65.3
221-24787.26.66.25.95.4
248-2928.57.676.56.15.6
293-3999.58.37.576.55.9
400-1397511.9108.88.17.56.7
Adjustable Factor Table (Martin/Hopkins TG:VLDL-C Ratio Grid)

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