Integrated LDL-Cholesterol Calculator (Friedewald / Martin-Hopkins / Sampson)
Friedewald: LDL = TC – HDL – (TG/5)
Martin-Hopkins: LDL = TC – HDL – (TG / adjustable factor)
Sampson: LDL = (TC / 0.948) – (HDL / 0.971) – ((TG / 8.56) + (TG × non-HDL / 2140) – (TG² / 16100) – 9.44
Non-HDL = TC – HDL
* If TG ≥ 400 mg/dL, LDL-C values using Friedewald and Martin-Hopkins formulas may be inaccurate. Use with caution!
Reference :
Martin SS, Blaha MJ, Elshazly MB, et al. Comparison of a Novel Method vs the Friedewald Equation for Estimating Low-Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile. JAMA. 2013;310(19):2061–2068. doi:10.1001/jama.2013.280532
Sampson M, Ling C, Sun Q, et al. A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia. JAMA Cardiol. 2020;5(5):540–548. doi:10.1001/jamacardio.2020.0013
| Non-HDL-C (mg/dL) | ||||||
| TG (mg/dL) | <100 | 100–129 | 130–159 | 160–189 | 190–219 | ≥220 |
| 7-49 | 3.5 | 3.4 | 3.3 | 3.3 | 3.2 | 3.1 |
| 50-56 | 4 | 3.9 | 3.7 | 3.6 | 3.6 | 3.4 |
| 57-61 | 4.3 | 4.1 | 4 | 3.9 | 3.8 | 3.6 |
| 62-66 | 4.5 | 4.3 | 4.1 | 4 | 3.9 | 3.9 |
| 67-71 | 4.7 | 4.4 | 4.3 | 4.2 | 4.1 | 3.9 |
| 72-75 | 4.8 | 4.6 | 4.4 | 4.2 | 4.2 | 4.1 |
| 76-79 | 4.9 | 4.6 | 4.5 | 4.3 | 4.3 | 4.2 |
| 80-83 | 5 | 4.8 | 4.6 | 4.4 | 4.3 | 4.2 |
| 84-87 | 5.1 | 4.8 | 4.6 | 4.5 | 4.4 | 4.3 |
| 88-92 | 5.2 | 4.9 | 4.7 | 4.6 | 4.4 | 4.3 |
| 93-96 | 5.3 | 5 | 4.8 | 4.7 | 4.5 | 4.4 |
| 97-100 | 5.4 | 5.1 | 4.8 | 4.7 | 4.5 | 4.3 |
| 101-105 | 5.5 | 5.2 | 5 | 4.7 | 4.6 | 4.5 |
| 106-110 | 5.6 | 5.3 | 5 | 4.8 | 4.6 | 4.5 |
| 111-115 | 5.7 | 5.4 | 5.1 | 4.9 | 4.7 | 4.5 |
| 116-120 | 5.8 | 5.5 | 5.2 | 5 | 4.8 | 4.6 |
| 121-126 | 6 | 5.5 | 5.3 | 5 | 4.8 | 4.6 |
| 127-132 | 6.1 | 5.7 | 5.3 | 5.1 | 4.9 | 4.7 |
| 133-138 | 6.2 | 5.8 | 5.4 | 5.2 | 5 | 4.7 |
| 139-146 | 6.3 | 5.9 | 5.6 | 5.3 | 5 | 4.8 |
| 147-154 | 6.5 | 6 | 5.7 | 5.4 | 5.1 | 4.8 |
| 155-163 | 6.7 | 6.2 | 5.8 | 5.4 | 5.2 | 4.9 |
| 164-173 | 6.8 | 6.3 | 5.9 | 5.5 | 5.3 | 5 |
| 174-185 | 7 | 6.5 | 6 | 5.7 | 5.4 | 5.1 |
| 186-201 | 7.3 | 6.7 | 6.2 | 5.8 | 5.5 | 5.2 |
| 202-220 | 7.6 | 6.9 | 6.4 | 6 | 5.6 | 5.3 |
| 221-247 | 8 | 7.2 | 6.6 | 6.2 | 5.9 | 5.4 |
| 248-292 | 8.5 | 7.6 | 7 | 6.5 | 6.1 | 5.6 |
| 293-399 | 9.5 | 8.3 | 7.5 | 7 | 6.5 | 5.9 |
| 400-13975 | 11.9 | 10 | 8.8 | 8.1 | 7.5 | 6.7 |